Dual Modality Imaging
Dual-Modality Imaging
Being an all-optical imaging microscope, PARS microscopy has the potential to be combined with other imaging modalities to provide complementary imaging contrasts and offer direct optical absorption properties of tissue chromophores. One of the well-known optical imaging modalities that can provide parallel imaging contrast to PARS and offers depth-resolved scattering information, is optical coherence tomography (OCT). OCT obtains its imaging contrast purely from reflected and backscattered light coming from different layers of the tissue. It has demonstrated the ability for acquiring volumetric images within a few seconds together with high sensitivity and phase information required for functional OCT extensions. Over the past 28 years, OCT technology has improved tremendously and became a powerful state-of-the art clinical imaging modality for various applications specially for ophthalmic imaging. Despite offering highly sensitive scattering contrast, OCT technology suffers from being insensitive to light absorption inside the tissue. In our lab, we are developing a dual-modality imaging system by integrating PARS microscopy and optical coherence tomography. The system has great potential for a wide range of pre-clinical and clinical applications and offer a direction for future microscopes development and may open up new opportunities for functional and molecular imaging in developmental biology, ophthalmology, or dermatology.
Being an all-optical imaging microscope, PARS microscopy has the potential to be combined with other imaging modalities to provide complementary imaging contrasts and offer direct optical absorption properties of tissue chromophores. One of the well-known optical imaging modalities that can provide parallel imaging contrast to PARS and offers depth-resolved scattering information, is optical coherence tomography (OCT). OCT obtains its imaging contrast purely from reflected and backscattered light coming from different layers of the tissue. It has demonstrated the ability for acquiring volumetric images within a few seconds together with high sensitivity and phase information required for functional OCT extensions. Over the past 28 years, OCT technology has improved tremendously and became a powerful state-of-the art clinical imaging modality for various applications specially for ophthalmic imaging. Despite offering highly sensitive scattering contrast, OCT technology suffers from being insensitive to light absorption inside the tissue. In our lab, we are developing a dual-modality imaging system by integrating PARS microscopy and optical coherence tomography. The system has great potential for a wide range of pre-clinical and clinical applications and offer a direction for future microscopes development and may open up new opportunities for functional and molecular imaging in developmental biology, ophthalmology, or dermatology.