Pharmaceutical Development
Angiogenesis Imaging:
A tumor, in order to grow and reach the metastatic spread phase, needs to develop an independent blood network to supply nutrients and oxygen and to remove waste products. The growth of these abnormal blood vessels is called angiogenesis. Angiogenesis plays a significant role in tumor growth and metastasis. Tumor growth and metastasis are responsible for more than 90% of cancer death. As a result, angiogenesis has become one of the heavily funded areas of medical research in history. Because haemoglobin provides ~ 2 orders of magnitude higher optical absorption compared to surrounding tissues, photoacoustic imaging is one of the best solutions for imaging blood vessels and angiogenesis. In our lab we are working on longitudinal structural and functional angiogenesis studies. One of primary research direction is to test and analyze the angiogenesis inhibitor effectiveness by novel imaging techniques.
A tumor, in order to grow and reach the metastatic spread phase, needs to develop an independent blood network to supply nutrients and oxygen and to remove waste products. The growth of these abnormal blood vessels is called angiogenesis. Angiogenesis plays a significant role in tumor growth and metastasis. Tumor growth and metastasis are responsible for more than 90% of cancer death. As a result, angiogenesis has become one of the heavily funded areas of medical research in history. Because haemoglobin provides ~ 2 orders of magnitude higher optical absorption compared to surrounding tissues, photoacoustic imaging is one of the best solutions for imaging blood vessels and angiogenesis. In our lab we are working on longitudinal structural and functional angiogenesis studies. One of primary research direction is to test and analyze the angiogenesis inhibitor effectiveness by novel imaging techniques.
In vivo images of the CAM from a chicken embryo. (a) En-face C-scan PARS images (b) A snapshot of real-time imaging of capillaries at 30 FPS. (c) PARS™ images of a melanoma tumor and surrounding vasculature. Scale bar: 100 μm. [Light: Science & Applications 6.6 (2017): e16278]